1
Question
Which of the following is a common feature between glycolysis and Krebs cycle?
Which of the following is a common feature between glycolysis and Krebs cycle?
Open in App
Solution
The correct option is D dehydrogenation
In the 6th step of glycolysis, glyceraldehyde-3-phosphate is oxidised through the removal of hydrogen in the presence of enzyme glyceraldehyde-3-phosphate dehydrogenase. It is also phosphorylated to form 1,3-bisphosphoglycerate. NADH (reduced nicotinamide adenine dinucleotide) is produced in this step.
In the 8th step of Krebs cycle, oxidation of malate occurs. Malate is dehydrogenated or oxidised through the agency of malate dehydrogenase to produce oxaloacetate. H+ is accepted by NAD+. NADH (reduced nicotinamide adenine dinucleotide) is formed in this step.
In the 3rd step of Krebs cycle there is formation of 𝝰-ketoglutarate. Isocitrate undergoes oxidative decarboxylation (removal of carboxyl group in the form of released CO2) in the presence of enzyme isocitrate dehydrogenase and Mn2+. A transient oxalosuccinate is formed as intermediate. It undergoes decarboxylation to form a 5- carbon 𝝰-ketoglutarate also known as 2-oxoglutarate. NADH (reduced nicotinamide adenine dinucleotide) is produced in this step.
In the 4th step of Krebs cycle there is oxidative decarboxylation (removal of carboxyl group in the form of released CO2) of 𝝰-ketoglutarate. In this step, 𝝰-ketoglutarate is both dehydrogenated (with the help of NAD+) and decarboxylated by an enzyme complex 𝝰-ketoglutarate dehydrogenase. The product combines with CoA to form succinyl CoA. NADH (reduced nicotinamide adenine dinucleotide) is produced.
In the 6th step of Krebs cycle, oxidation of succinate occurs. Succinate undergoes dehydrogenation to form fumarate with the help of a membrane based enzyme succinate dehydrogenase. FADH2 is produced in this step.
Glycolysis occurs in cytoplasm, Krebs cycle occurs in mitochondria.
So, we can see that nothing is common to glycolysis and Krebs cycle, except the dehydrogenation process.
In the 6th step of glycolysis, glyceraldehyde-3-phosphate is oxidised through the removal of hydrogen in the presence of enzyme glyceraldehyde-3-phosphate dehydrogenase. It is also phosphorylated to form 1,3-bisphosphoglycerate. NADH (reduced nicotinamide adenine dinucleotide) is produced in this step.
In the 8th step of Krebs cycle, oxidation of malate occurs. Malate is dehydrogenated or oxidised through the agency of malate dehydrogenase to produce oxaloacetate. H+ is accepted by NAD+. NADH (reduced nicotinamide adenine dinucleotide) is formed in this step.
In the 3rd step of Krebs cycle there is formation of 𝝰-ketoglutarate. Isocitrate undergoes oxidative decarboxylation (removal of carboxyl group in the form of released CO2) in the presence of enzyme isocitrate dehydrogenase and Mn2+. A transient oxalosuccinate is formed as intermediate. It undergoes decarboxylation to form a 5- carbon 𝝰-ketoglutarate also known as 2-oxoglutarate. NADH (reduced nicotinamide adenine dinucleotide) is produced in this step.
In the 4th step of Krebs cycle there is oxidative decarboxylation (removal of carboxyl group in the form of released CO2) of 𝝰-ketoglutarate. In this step, 𝝰-ketoglutarate is both dehydrogenated (with the help of NAD+) and decarboxylated by an enzyme complex 𝝰-ketoglutarate dehydrogenase. The product combines with CoA to form succinyl CoA. NADH (reduced nicotinamide adenine dinucleotide) is produced.
In the 6th step of Krebs cycle, oxidation of succinate occurs. Succinate undergoes dehydrogenation to form fumarate with the help of a membrane based enzyme succinate dehydrogenase. FADH2 is produced in this step.
Glycolysis occurs in cytoplasm, Krebs cycle occurs in mitochondria.
So, we can see that nothing is common to glycolysis and Krebs cycle, except the dehydrogenation process.