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Question

Which of the following is a mismatch?


A

Live R strain - Non-virulent

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B

Heat-killed R strain - Virulent

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C

Live S strain - Pathogenic

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D

Heat-killed S strain - Non-pathogenic

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Solution

The correct option is B

Heat-killed R strain - Virulent


Griffith considered two different strains of the bacterium Streptococcus pneumoniae - S strain and R strain. The former is pathogenic/virulent and can cause the disease, while the latter is non-pathogenic/non-virulent and cannot cause the disease. Heat-killed S strain bacteria however, lose their virulence and become non-pathogenic. R strain bacteria in general, don’t need to be heat-killed as they are already non-pathogenic.


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