Question

Which of the following is an example of a pleiotropy?

• A. Haemophilia
• B. Thalassemia
• C. Sickle cell anemia
• D. Colour blindness

Answer 1

The correct option is C Sickle cell anemia

The situation where the expression of a single gene has multiple phenotypic effects is called pleiotropy. Out of the given diseases, sickle cell anemia shows pleiotropy. In sickle cell anemia, 𝛃- chain of hemoglobin gets mutated at the $6^{\mathrm{th}}$ position (substituting valine for glutamic acid) and also distorts the structure of the R.B.Cs.