The correct options are
A Use of harmful psychoactive drugs adversely affects brain
B Drug dependence and its abuse strongly connects to crime in society
C Drug abuse causes physical trauma which affects health drastically
Substance abuse, also known as drug abuse is a patterned use of a drug in which the user consumes the substance in amounts or with methods which are harmful to themselves or others and is a form of substance related disorder. This disorder causes severe physical trauma which affects their brain and also health.