The correct option is A Expression
Fermentation is conducted in fermentor for the production of target microbial product. The target gene in the microorganism is expressed during this process.
Downstream process is the process of separation and purification of products synthesised in fermentor. After the completion of bioynthetic stage, the product has to be subjected through a series of processes before it is ready for marketing as a finished product. The processes include separation and purification, collectively referred to as downstream processing. The product is then formulated with suitable preservatives.
So expression is part of not a component of downstream processing.