Question

Which of the following is the example of a pleiotropic disease?

• A. Haemophilia
• B. Thalassemia
• C. Sickle cell anaemia
• D. Colour blindness

Answer 1

The correct option is C Sickle cell anaemia

Pleiotropy is the phenomenon where one gene influences two or more seemingly unrelated phenotypic traits.
Sickle cell anemia is a pleiotropic disease.
Cells of a suffering individual contain two copies of abnormal genes. Hence, the cells have a low oxygen carrying capacity and thus impairing circulation. This also leads to renal failure, cardiac failure, and thrombosis.
Haemophilia and color blindness are x-linked diseases.
Where as Thalassemia, is an autosomal disease.