Question

Which of the following is the transition state structure of the substrate formed during an enzymatic reaction?

• A. Permanent but unstable
• B. Transient and unstable
• C. Permanent and stable
• D. Transient but stable

Answer 1

The correct option is B Transient and unstable

Reactions do not undergo chemical changes automatically. They do so in transition states. Transition state has more free energy than reactants or products. Higher free energy helps in collision of transition state reactants. The enzymes binds to substrate molecules and form an unstable transient state called as transition state. The transition state rapidly undergoes degeneration into products and unchanged enzyme molecule.