Question

Which of the following is used as a modification by dehydrogenase enzyme in cell respiration?

• A. Thiamine
• B. Riboflavin
• C. Pyridoxine
• D. Cyanocobalamin

Answer 1

The correct option is A Thiamine

Thiamine is used as a modification by dehydrogenase enzyme in cell respiration. The oxidation of pyruvate occurs in the mitochondria of the cell The mitochondria is an organelle in the cell. It is considered the 'powerhouse' of the cell. Pyruvate is transported there via pyruvate translocase. Pyruvate dehydrogenase is a multi enzyme complex that uses three enzymes:

1. $E_1$: Pyruvate dehydrogenase, which uses thiamine pyrophosphate as its prosthetic group.
2. $E_2$: Dihydrolipoyl transacetylase, which uses lipoamide and coenzyme A as its prosthetic groups.
3. $E_3$: Dihydrolipoyl dehydrogenase, which uses flavin adenine dinucelotide and nicotinamide adenine dinucleotide as its cofactors.