Which of the following local hormone is a lipid substance and plays an important role in inflammatory response and fever?
A
Prostaglandins
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B
Histamine
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C
ANF
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D
None of the above
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Solution
The correct option is A Prostaglandins
The prostaglandins (PG) are a group of physiologically active lipid-soluble compounds called eicosanoids.
Prostaglandins are one of the more potent mediators of inflammation that cause increased blood flow, chemotaxis (chemical signals that summon white blood cells), and subsequent dysfunction of tissues and organs.
Temperature is ultimately regulated in the hypothalamus. A trigger of the fever, called a pyrogen, causes the release of prostaglandin E2 (PGE2).
Hence the local hormone which is a lipid substance and plays an important role in inflammatory response and fever is Prostaglandins.