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Question

Which of the following local hormone is a lipid substance and plays an important role in inflammatory response and fever?

A
Prostaglandins
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B
Histamine
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C
ANF
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D
None of the above
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Solution

The correct option is A Prostaglandins
  • The prostaglandins (PG) are a group of physiologically active lipid-soluble compounds called eicosanoids.
  • Prostaglandins are one of the more potent mediators of inflammation that cause increased blood flow, chemotaxis (chemical signals that summon white blood cells), and subsequent dysfunction of tissues and organs.
  • Temperature is ultimately regulated in the hypothalamus. A trigger of the fever, called a pyrogen, causes the release of prostaglandin E2 (PGE2).
  • Hence the local hormone which is a lipid substance and plays an important role in inflammatory response and fever is Prostaglandins.
  • So, the correct answer is 'Option A'.

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