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Question
Which of the following parts of a digested antibody can still perform the activity of a whole antibody?
Which of the following parts of a digested antibody can still perform the activity of a whole antibody?
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Solution
The correct option is A F(ab)2 region
Whenever an antibody like IgG is subjected to proteolytic digestion, the enzyme targets the hinge regions of the antibody most prominently and cleaves the immunoglobulin into fragments such as Fab, F(ab)2 and Fc.
F(ab)2 are divalent antibody fragments that have both the antigen binding sites intact but the constant region of the heavy chain is fragmented out. F(ab)2 can still perform the activity of the whole antibody even after leaving the constant region of the heavy chain from below the hinge region.
Fab is the monovalent fragment of the antibody, whose variable regions of both the heavy and light chain of one arm of the antibody remain intact but its connection with its alternate arm of the Y shaped antibody gets cleaved. That is why Fab cannot perform the activity of a whole antibody and cannot disarm or fight an antigen.
Neither Fc region alone can perform the activity of a whole antibody nor can a heavy chain alone do it.
Whenever an antibody like IgG is subjected to proteolytic digestion, the enzyme targets the hinge regions of the antibody most prominently and cleaves the immunoglobulin into fragments such as Fab, F(ab)2 and Fc.
F(ab)2 are divalent antibody fragments that have both the antigen binding sites intact but the constant region of the heavy chain is fragmented out. F(ab)2 can still perform the activity of the whole antibody even after leaving the constant region of the heavy chain from below the hinge region.
Fab is the monovalent fragment of the antibody, whose variable regions of both the heavy and light chain of one arm of the antibody remain intact but its connection with its alternate arm of the Y shaped antibody gets cleaved. That is why Fab cannot perform the activity of a whole antibody and cannot disarm or fight an antigen.
Neither Fc region alone can perform the activity of a whole antibody nor can a heavy chain alone do it.
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