Question

Which of the following property of plasma membrane of erythrocyte help in Hamburger phenomenon:-

• A. Chloride shift
• B. Haldane effect
• C. Bohr effect
• D. Donan Phenomenon

Answer 1

The correct option is A Chloride shift

• Due to the permeability of plasma membrane of RBC to anions, $HC{O}_3^{-}$ diffuse into the blood plasma from RBC at the tissues. The $H^{+}$ ions are buffered by hemoglobin which turns into HHb(acid hemoglobin).
• Hemoglobin acts as a buffer at physiological pH because of its high content of histidine.
• As a result, the molecules lose their affinity for oxygen and so $O_2$ is released. It diffuses into the plasma and from there into the tissues.
• To maintain electrical balance $C{l}^{-}$ ions diffuse from plasma into RBC. This exchange of chloride and bicarbonate ions between RBC and plasma at tissue level is called chloride shift or hamburger's phenomenon.
• Hence Chloride shifts property of plasma membrane of erythrocyte help in Hamburger phenomenon.
• So, the correct answer is 'Chloride shift'.