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Question

Which of the following ratios does not change in DNA?

A
Cytosine : Adenine
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B
Pyrimidine : Purine
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C
Adenine : Guanine
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D
Guanine : Deoxyribose
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E
Thymine : Guanine
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Solution

The correct option is A Pyrimidine : Purine
According to Chargaff’s rule all cellular DNAs, regardless of the species, number of adenosine residues is equal to number of thymidine residues which means that A=T; and the number of guanosine residues is equal to the number of cytidine residues; G= C. Hence that the sum of the purine residues equals the sum of the pyrimidine residues; i.e., A + G= T + C; this means that purine to pyrimidine (A+G/T+C) or pyrimidine to purine ratio (T+C/A+G) is constant for a species. So, the correct answer is option B.

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