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Question

Which of the following regarding DNA replication, is/are correct?


A

Both the strands of the parental DNA double helix serve as templates

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B

On the template with polarity 3’ 5’, replication is continuous

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C

On the template with polarity 5’ 3’, replication is discontinuous

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D

All the above

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Solution

The correct option is D

All the above


During DNA replication, both the strands of the parental DNA double helix serve as templates. A template strand is simply the strand from which a new complementary strand is synthesised. Complementary to the 3 5’ template, the leading strand is synthesised along the 5 3’ direction. The lagging strand is synthesised discontinuously, and complementary to the 5’ 3’ template. Ultimately, one round of DNA replication results in the splitting of a single parental DNA molecule to form two daughter DNA double helices, exactly identical to the parental DNA.


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