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Question

Which of the following required for binding protein with nucleic acid?

A
Nickel
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B
Iron
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C
Cobalt
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D
Calcium
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Solution

The correct option is D Calcium

Many enzymes acting on DNA require Mg2+ ions not only for catalysis but also to bind DNA. Ca2+ acts as a substitute for Mg2+ to promote DNA binding. The Sfi-1 endonuclease requires divalent metal ions to bind DNA but, in contrast to many systems where Ca2+ mimics Mg2+, Ca2+ causes Sfi-1 to bind DNA almost irreversibly. Hence the correct option is D.


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