The correct option is
C DiGeorge syndrome
DiGeorge syndrome results in the congenital (present at birth) defect of the thymus in humans. This disability occurs when a small piece of chromosome number 22 is found (22q11) deleted. Symptoms include several abnormalities, like heart defects, characteristic facial features, breathing problems, underdevelopment or absence of parathyroid and thymus gland.
![](https://df0b18phdhzpx.cloudfront.net/ckeditor_assets/pictures/1364170/original_DiGeorge_Syndrome.png)
Figure : DiGeorge syndrome
When the thymus fails to develop, it results in the total absence of T-lymphocytes because thymus is required for the maturation and selection of T-lymphocytes. This affects the cell-mediated immunity.
Down's syndrome resulted due to the trisomy (3 copies) of chromosome number 21. Symptoms include distinct facial appearance, intellectual disability, and developmental delays.
![](https://df0b18phdhzpx.cloudfront.net/ckeditor_assets/pictures/1364237/original_Disease.png)
Figure : Down's syndrome
Cystic fibrosis is a condition caused by mutations in cystic fibrosis transmembrane conductance regulator (CFTR) gene. Mucus gets thick and blocks the tracts because of the absence of a chloride channel in this disorder.
![](https://df0b18phdhzpx.cloudfront.net/ckeditor_assets/pictures/1364204/original_Cystic_fibrosis.png)
Figure : Cystic fibrosis
Fragile X syndrome is a disease caused due to changes in the FMR1 gene. This gene makes a protein called FMRP which is needed for brain development. Symptoms include developmental delays, learning disabilities, social and behavioural problems like anxiety, speaking without thinking, and being hyperactive.
![](https://df0b18phdhzpx.cloudfront.net/ckeditor_assets/pictures/1364194/original_Fragile_X_syndrome.png)
Figure : Fragile X syndrome