Which of the following set of enzymes act as catalyst for the conversion of pyruvic acid into acetaldehyde and ethyl alcohol?
A
Pyruvic acid decarboxylase and alcohol decarboxylase
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B
Pyruvic acid decarboxylase and alcohol dehydrogenase
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C
Pyruvic acid dehydrogenase and alcohol decarboxylase
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D
Pyruvic acid dehydrogenase and alcohol dehydrogenase
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Solution
The correct option is B Pyruvic acid decarboxylase and alcohol dehydrogenase Pyruvic acid decarboxylase and alcohol dehydrogenase enzymes act as catalysts for the conversion of pyruvic acid into acetaldehyde and ethyl alcohol respectively. Pyruvate decarboxylase is the enzyme responsible for the non-oxidative decarboxylation of pyruvate to acetaldehyde and carbon dioxide. The acetaldehyde is often then reduced by alcohol dehydrogenase to make ethanol.
Pyruvic acid dehydrogenase converts pyruvate to acetyl CoA. This increases the influx of acetyl CoA into the TCA cycle. Alcohol decarboxylase catalyzes the decarboxylation.