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Conjugate Enzymes

Which of the ...

Question

Which of the following statement is not true :-

A

Co-enzymes are organic compound

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B

Association between apoenzyme and co-enzyme is permanent

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C

NADP contain the vitamin niacin

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D

Prosthetic group binds tightly to the apoenzyme

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Solution

The correct option is D Association between apoenzyme and co-enzyme is permanent
Association between apoenzyme and co enzyme is not permanent.
Co-enzymes are non-protein organic molecules which are mostly derivatives of vitamins soluble in water by phosphorylation. They bind apoenzyme to proteins to produce an active holoenzyme. A holoenzyme refers to a catalytically active enzyme that consists of both apoenzyme (enzyme without its cofactor(s) and cofactor.
So, the correct option is 'Associated between apoenzyme and co-enzyme is permanent'.

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Q. Complete the following passage(s) with an appropriate word/term to be filled in the blank spaces.
Apoenenzyme, Polypeptide, Prosthetic, Co-enzyme, Cofactors
Enzymes are composed of one or several .......... (1) ........ chains. However, there are a number of cases in which non-protein constituents called ........(2)........ are bound to the the enzyme to make the enzyme catalytically active. In these instances, the protein portion of the enzymes is called the ..........(3)......... Three kinds of cofactors may be identified prosthetic groups, co-enzymes and metal ions. ..........(4).......... groups are organic compounds and are distinguished from other cofactors in that they are tightly bound to the apoenzyme. For example, in peroxidase and catalase, which catalyze the breakdown of hydrogen peroxide to water and oxygen, haem is the prosthetic group and it is a part of the active site of the enzyme. .......(5)......... are also organic compounds but their association with the apoenzyme is only transient, usually occurring during the course of catalysis, Furthermore co-enzymes serve as co-factors in a number of different enzyme catalyzed reactions. The essential chemical components of many coenzymes are vitamins, e.g., coenzyme nicotinamide adenine dinucleotide (NAD) and NADP contain the vitamin niacin.

Q. Assertion :A coenzyme or metal ion tightly bound to enzyme protein is called prosthetic group. Reason: A complete catalytically active enzyme together with its bound prosthetic group is called apoenzyme.

Q. Assertion :A coenzyme or metal ion that is very tightly bound to enzyme protein called prosthetic group. Reason: A complete, catalytically active enzyme together with its bound prosthetic group is called apoenzyme.

Q. Assertion :Coenzyme nicotinamide adenine dinucleotide (NAD) and NADP contain a vitamin. Reason: The association of co-enzyme with apoenzyme is enduring.

Q. Assertion (A): A coenzyme or metal ion that is very tightly bound to enzyme protein is called prosthetic group.
Reason (R): A complete catalytically active enzyme together with its bound prosthetic group is called apoenzyme.

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