Which of the following statements is not true about enzyme inhibitors?
(a) Inhibit the catalytic activity of the enzyme
(b) Prevent the binding of substrate
(c) Generally a strong covalent bond is formed between an inhibitor and an enzyme
(d) Inhibitors can be competitive or non-competitive

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Solution

Answer: (c).

Inhibitors are chemical substances which tend to reduce the activity of a particular enzyme. Generally, a weak bond such as H-bonding, Van der Waals interaction, etc. is formed between the enzyme and the inhibitor.

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Non-competitive inhibitor changes the active site of enzyme after binding at:

Column I	Column II
(A) Active site	(p) inactivates an enzyme by changing the enzymes's shape
(B) Alosteric inhibitor	(q) inactivates an enzyme by denaturing it
(C) Competitive inhibitor	(r) inactivates an enzyme by occupying its active site
(D) Substrate	(s) holds the substrate during the reaction
(E) Irreversible inhibitor	(t) molecules acted upon by an enzyme

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