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Question

Which of the following substances yield less than 4 Kcal/mol when its phosphate bond is hydrolysed?

A
Creatine phosphate
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B
ADP
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C
Glucose-6-phosphate
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D
ATP
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Solution

The correct option is B Glucose-6-phosphate
The process of glycolysis involves the conversion of glucose to glucose-6-phosphate. The reaction can be written as follows:
Image ch2e13.jpg
The reaction which the hydrolysis of the phosphate bond in ATP takes place gives rise to free energy range of 7.3 kcal/mol, when ADP is hydrolysed, the reaction also gives free energy in the range of 7.3 kcal/mol. Creatine Phosphate is also a high energy phosphate compound. The reason for high free energy is due to difference of free energy contents in reactants and products. However, the low energy phosphates include glucose-1-P, fructose-6-P, glucose-6-P and AMP. Hydrolysis of Glucose 6-P gives an yield of -3.3 kcal/mol

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