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Question
Which of the following type of cell actively participates in hypersensitivity type IV reaction?
Which of the following type of cell actively participates in hypersensitivity type IV reaction?
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Solution
The correct option is D Both A and B
Type IV hypersensitivity also called delayed type hypersensitivity is a type of cell-mediated response. CD4+ helper T cells recognize antigen in a complex with Class II major histocompatibility complex. The antigen-presenting cells are macrophages that secrete IL-12. IL-12 stimulates the proliferation of CD4+ T helper cells. These cells secrete IL-2 and interferon gamma, further inducing the release of other Th cytokines, hence mediating the immune response. Activated CD8+ T killer cells then destroy target cells on contact. Thus the correct answer is option D.
Type IV hypersensitivity also called delayed type hypersensitivity is a type of cell-mediated response. CD4+ helper T cells recognize antigen in a complex with Class II major histocompatibility complex. The antigen-presenting cells are macrophages that secrete IL-12. IL-12 stimulates the proliferation of CD4+ T helper cells. These cells secrete IL-2 and interferon gamma, further inducing the release of other Th cytokines, hence mediating the immune response. Activated CD8+ T killer cells then destroy target cells on contact. Thus the correct answer is option D.
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