Question

Which of the following vector was used in the first clinical treatment of adenosine deaminase (ADA) deficiency through gene therapy?

• A. Bacteriophage
• B. Lamda phage
• C. Plasmid vector
• D. Retroviral vector

Answer 1

The correct option is D Retroviral vector

Retroviral vector was used in the clinical treatment of adenosine deaminase (ADA) deficiency through gene therapy. As a first step, lymphocytes from the blood of the patient were grown in a culture outside the body. A functional ADA cDNA was then introduced into the lymphocytes which are subsequently introduced into the patient.