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Question
Which of the following was the first restriction endonuclease to be isolated and characterised?
Which of the following was the first restriction endonuclease to be isolated and characterised?
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Solution
The correct option is D Hind Ⅱ
Restriction endonucleases are naturally present in the bacterial system, where they provide defence against the invading bacteriophage DNA. Endonucleases recognize specific palindromic nucleotide sequences in a DNA and cleaves the DNA at a particular nucleotide within the palindromic sequence.
Hind Ⅱ was the first restriction endonuclease to be isolated and characterised from the bacterium Haemophilus influenzae Rd strain Ⅱ, by Hamilton O. Smith, Thomas Kelly and Kent Wilcox in 1970.
Restriction endonucleases are naturally present in the bacterial system, where they provide defence against the invading bacteriophage DNA. Endonucleases recognize specific palindromic nucleotide sequences in a DNA and cleaves the DNA at a particular nucleotide within the palindromic sequence.
Hind Ⅱ was the first restriction endonuclease to be isolated and characterised from the bacterium Haemophilus influenzae Rd strain Ⅱ, by Hamilton O. Smith, Thomas Kelly and Kent Wilcox in 1970.
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