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Question
Which of the given processes is a component of upstream processing of desired gene product?
Which of the given processes is a component of upstream processing of desired gene product?
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Solution
The correct option is D Expression of the gene
Obtaining the foreign gene product from a living source, here, genetically engineered organism, is known as bioprocessing. It consists of two stages- upstream processing and downstream processing.
Upstream processing includes all the processes in which the raw materials are biologically converted into specific products by using microbial, plant or animal cells.
Expression of the foreign gene within a genetically engineered organism occurs at a large scale in the culture medium inside a bioreactor. This is the biosynthetic phase and is a component of the upstream processing.
Once the concentration or density of the product expressed by the host cells in the culture reaches the optimal quantity, it needs to be extracted out for use.
Separation of the expressed gene product from the culture media and its purification are done. Separation and purification are the components of downstream processing.
Downstream processing is followed by formulation of the desired product with preservatives to increase its shelf life. This is further followed by strict clinical trials and quality control measures.
Obtaining the foreign gene product from a living source, here, genetically engineered organism, is known as bioprocessing. It consists of two stages- upstream processing and downstream processing.
Upstream processing includes all the processes in which the raw materials are biologically converted into specific products by using microbial, plant or animal cells.
Expression of the foreign gene within a genetically engineered organism occurs at a large scale in the culture medium inside a bioreactor. This is the biosynthetic phase and is a component of the upstream processing.
Once the concentration or density of the product expressed by the host cells in the culture reaches the optimal quantity, it needs to be extracted out for use.
Separation of the expressed gene product from the culture media and its purification are done. Separation and purification are the components of downstream processing.
Downstream processing is followed by formulation of the desired product with preservatives to increase its shelf life. This is further followed by strict clinical trials and quality control measures.
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