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Question
Which of these cause chills and fever in malaria?
Which of these cause chills and fever in malaria?
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Solution
The correct option is B Haemozoin
Malaria parasites use hemoglobin as a major nutrient source in the intraerythrocytic stage, during which heme is converted to hemozoin, an iron-containing pigment, which accumulates as cytoplasmic granules in the parasites. These are dumped into the bloodstream, when the infected cells lyse and release invasive merozoites. The hemozoin and other toxic factors such as glucose phosphate isomerase (GPI) stimulate macrophages and other cells to produce cytokines and other soluble factors, which act to produce fever and rigors and probably influence other severe pathophysiology associated with malaria.
So, answer is - 'Haemozoin'.
Malaria parasites use hemoglobin as a major nutrient source in the intraerythrocytic stage, during which heme is converted to hemozoin, an iron-containing pigment, which accumulates as cytoplasmic granules in the parasites. These are dumped into the bloodstream, when the infected cells lyse and release invasive merozoites. The hemozoin and other toxic factors such as glucose phosphate isomerase (GPI) stimulate macrophages and other cells to produce cytokines and other soluble factors, which act to produce fever and rigors and probably influence other severe pathophysiology associated with malaria.
So, answer is - 'Haemozoin'.
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