Which of these steps in Krebs cycle indicates substrate level phosphorylation? Conversion of
A
Succinic acid to α-ketoglutaric acid
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B
Succinic acid to malic acid
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C
Succinyl CoA to succinic acid
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D
malic acid to oxaloacetic acid
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E
Citric acid to α-ketoglutaric acid
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Solution
The correct option is C Succinyl CoA to succinic acid In Krebs cycle, during the conversion of Succinyl-CoA to succinic acid, GTP is produced from GDP which being unstable immediately changes to ATP. Since ATP synthesis takes place without entering ETC directly by the substrate, it is known as substrate-level phosphorylation.