Which one of the following does not involve isomerisation in glycolysis pathway?
A
Conversion of glucose-6-phosphate to fructose-6-phosphate
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B
Conversion of glycerol aldehyde-3-phosphate to dihydroxyacetone phosphate
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C
Conversion of 3-phosphoglyceric acid to 2-phosphoglyceric acid
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D
Conversion of 2-phosphoglyceric acid to phospho enol pyruvic acid
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Solution
The correct option is D
Conversion of 2-phosphoglyceric acid to phospho enol pyruvic acid
In the ninth step of glycolysis, 2-phosphoglyceric acid (2-PGA) is converted into phosphoenolpyruvic acid (PEP) by removal of one water molecule. These two molecules, 2-PGA and PEP are not isomers. All the other molecules mentioned here are isomers and their reactions are reversible, therefore they are interconvertible.