The correct option is D Creatinine
The chemical substances that are secreted by cells/tissues or glands are categorised as biological substances. It includes digestive juices, hormones and other secretions. Gastrin, thyroxin and oxytocin are the hormones secreted by stomach, thyroid gland and posterior pituitary respectively. These are biochemical substances. Creatinine is a breakdown product of creatine phosphate and does not fall under the biological category of chemical substances. Thus, the correct answer is D.