Which one of the following enzymes is responsible for the conversion of norepinephrine to epinephrine?

Catecholamine-O-methyltransferase

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Phenylalanine-N-methyltransferase

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DOPA decarboxylase

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Monoamine oxidase

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Solution

The correct option is B Phenylalanine-N-methyltransferase
Phenylethanolamine N-methyltransferase is an enzyme which converts norepinephrine to epinephrine. It is found in adrenal medulla. The gene encoding the enzyme is found on chromosome 17 in humans. It catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to norepinephrine, converting it into epinephrine. So, the correct answer is option B.

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