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Question

Which one of the following hormones never reaches to the cytoplasm?

A
Estrogen
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B
FSH
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C
Progesterone
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D
Testosterone
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Solution

The correct option is D FSH
All steroid hormones readily diffuse across the cell membrane. They can pass through the cell membrane as they are fat-soluble and then bind to steroid hormone receptors, which may be nuclear or cytosolic depending on the steroid hormone, to bring about changes within the cell. For example, Estrogen, progesterone, and testosterone. Whereas FSH is a glycoprotein hormone which is insoluble to the lipid content of the cell membrane and thus not able to reach the cytoplasm.

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