Which one of the following hydrolyze internal phosphodiester bonds in a polynucleotide chain?

Lipase

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Protease

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Exonuclease

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Endonuclease

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Solution

The correct option is D Endonuclease
Endonucleases hydrolyse internal phosphodiester bonds in a polynucleotide chain. Function of nucleases is to break phosphodiester bond. A nuclease is an enzyme capable of cleaving the phosphodiester bonds between the nucleotide subunits of nucleic acids. Nucleases are usually further divided into endonucleases and exonucleases, although some of the enzymes may fall in both categories.

Suggest Corrections

$I$	$I I$
$(a)$ Hydrogen bond	$(i)$ Adenine - deoxyric base
$(b)$ N-glycosidic linkage	$(i i)$ Glucose - Fructose
$(c)$ Phosphodiester bond	$(i i i)$ Leucine - Glycine
$(d)$ Peptide bond	$(i v)$ Nucleotide - Nucleotide in polynucleotide chain
	$(v)$ Guanine - Cytosin on opposite strands of DNA