The correct option is C Renin
Renin is a protease that catalyzes the conversion of angiotensinogen to angiotensin I by hydrolyzing a peptide (amide) bond. Renin is secreted by the kidney, but it's involved in arterial vasoconstriction (outside of kidney cells), so it is a hormone and it's also a peptide/enzyme, so it is considered both, a hormone and an enzyme.