Which one of the following is not a second messenger in hormone action?
Sodium
Certain hormones such as peptide hormones or catecholamines have a large molecular size, or due to extreme polarity, they are unable to cross the plasma membrane.
These hormones bind to the protein receptors present on the plasma membrane of the target cell.
Secondary messengers are present within the target cell and produce the effect of the hormone inside the cell.
As soon as the hormone binds to the receptors on the membrane, the secondary messengers are activated and their concentration in the cell increases.
cAMP acts as a secondary messenger when epinephrine binds to protein receptors on the plasma membrane.
Ca2+ ions also act as secondary messengers and are usually secreted into the cytoplasm by the endoplasmic reticulum. The presence of calcium in the cytoplasm triggers the effect of the hormone in the cell.
cGMP also acts as a secondary messenger and mediates many cell and tissue responses. Especially in the heart, it slows muscle contraction in response to acetylcholine.