Which one of the following is the correct sequence of events that follows in a Synaptic Transmission of Nerve impulse _____.
1. The membrane becomes depolarized
2. Voltage Calcium channels open
3. Release of Synaptic Vesicles
4. Diffusion of neurotransmitter across the synaptic cleft, binding to receptor proteins
on the postsynaptic membrane.
1,2,3,4
· When the action potential arrives at the axon terminals, the axonal membrane is depolarised.
· Depolarisation of the axonal membrane causes opening of the voltage gated Ca2+ channels present at the synapse.
· The influx of Ca2+ into the cell causes the synaptic vesicles present at the presynaptic membrane to fuse with the membrane and release the neurotransmitter contained in the vesicle to be released into the synaptic cleft.
· The neurotransmitter then diffuses across the synaptic cleft and binds to the receptors located on the postsynaptic membrane.