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Question

Which one of the following mammalian cells is not capable of metabolising glucose to carbon-dioxide aerobically?

A
Red blood cells
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B
White blood cells
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C
Unstriated muscle cells
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D
Liver cells
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Solution

The correct option is A Red blood cells
Human erythrocytes does not have mitochondria. Mitochondria are the cellular site for oxidative metabolism of fatty acids, erythrocytes cannot oxidise fatty acids to release energy. The erythrocytes cannot fully oxidise glucose (to carbon dioxide and water) because this is also a mitochondrial process, so they have to rely upon anaerobic glycolysis. The end product of anaerobic glycolysis is pyruvate and erythrocytes reduce this to lactate (to recycle the NADH that is produced during glycolysis) and then export this lactate into the blood for further metabolism by the liver.

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