The correct option is D Cortisol and testosterone
Cortisol and testosterone are examples of steroid hormones. Steroid hormones and iodothyronines are lipid soluble hormones. These can cross the cell membrane and enter the cell. They interact with intracellular receptors and regulate gene expression or chromosome function.
Thyroxine is an iodothyronine, and hence can cross the cell membrane. However, insulin and glucagon are protein hormones, and somatostatin and oxytocin are peptide hormones. Protein and peptide hormones are water soluble hormones.
Water soluble hormones interact with membrane bound receptors. They produce their effect by generating second messengers.