The correct option is C + and ×, 4 and 6
Applying
Option A:+ and x, 2 and 4.
6+2×4=6+8=14
This doesnot make the equation equal to 16
Option B :+ and , 2 and 6
2+4×6=8+6=14
This doesnot make the equation equal to 16
Option C:+ and , 4 and 6
4+6×2=4+12=16
Option C is correct
Answer is Option C