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Question

Which platinum complex is used in cancer chemotherapy?


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Solution

Platinum complex

  • The platinum coordination complexes are a type of anticancer drug that is typically classed as alkylating agents yet have unique properties.
  • Their anticancer action appears to be linked to cross-linking DNA molecules in a similar way to typical alkylating drugs.
  • Chemotherapy uses platinum complexes to treat cancer patients.

Cisplatin

  • Cisplatin was the first platinum chemical discovered to be an anticancer.
  • In cancer cells, the cisplatin binds to the reactive centre on purine residues, stopping cell division and ultimately death.
  • Structure of Cisplatin:

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