Question

Which processes of Krebs cycle are associated with both decarboxylation and dehydrogenation?

• A. Succinate $\to$ Fumarate and Fumarate $\to$ Malate
• B. Malate $\to$ Oxaloacetate and Succinate $\to$ Fumarate
• C. $\alpha$ -Ketoglutaric acid $\to$ Succinate and Malate $\to$ Oxaloacetate
• D. Isocitrate $\to$ $\alpha$ -Ketoglutaric acid and $\alpha$ -ketoglutaric acid $\to$ Succinate

Answer 1

The correct option is D

Isocitrate $\to$ $\alpha$ -Ketoglutaric acid and $\alpha$ -ketoglutaric acid $\to$ Succinate

Decarboxylation (removal of $C{O}_2$) and dehydrogenation (removal of $H_2$) occurs when iso-citrate is converted to α-ketogluoric acid and $\alpha$ - ketoglutaric acid is converted to succinate in Krebs cycle.