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Question

Who proposed the principle of "Induced fit"?

A
Jacob
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B
Fischer
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C
Koshland
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D
Laderberg
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Solution

The correct option is C Koshland
The induced-fit model is proposed by Daniel Koshland in 1958. It is the most accepted model for enzyme-substrate complex. It describes the formation of the Enzyme substrate as a result of the interaction between the substrate and a flexible active site which means exposure of an enzyme to a substrate causes the active site of the enzyme to change shape in order to allow the enzyme and substrate to bind. Hence option C is correct.

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