Scientists have discovered that the feeling experienced when we are tickled causes us to panic and is a natural defense to little creepy crawlers like spider and bugs. Slight tickles from insects can send a chill through your body letting you know something is crawling on you.
If we grab our sides in an attempt to tickle ourselves, our brain anticipates this contact from the hands and prepares itself for it. By taking away the feeling of unease and panic, the body no longer responds the same as it would if someone else were to tickle us.
The cerebellum in the backside of brain that prevents us from self-tickling. The cerebellum is the region located at the base of the brain that monitors our movements. It can distinguish expected sensations from unexpected sensations. An expected sensation would be the amount of pressure your fingers apply to your keyboard while typing. An unexpected sensation would be someone sneaking up behind you and tapping you on the shoulder. While the brain discards the sensation of typing, it pays a lot of attention to someone tapping on your shoulder. The difference in reactions from expected to unexpected is a built-in response that probably developed in early human history to detect predators.