The correct option is C Interference of Pope in politics led to clashes between emperors and the Pope.
The Catholic Church rose as the supreme power, and since the Pope started taking an interest in politics, there were severe clashes between the emperors and the Pope. The emperors wanted to stop the intervention of the Pope in politics and internal issues of countries. Thus, they supported the religious reformation movement as well. Tyranny of the Roman Catholic Church came to an end through the religious reformation.