Why do aircrafts flying at high altitude must have pressurize cabins
Pressurization is required for physiological reasons
Cabin pressurization is the active pumping of air into an aircraft cabin to increase the air pressure within the cabin. It is required when an aircraft reaches high altitudes, because the natural atmospheric pressure is too low to allow people to absorb sufficient oxygen, leading to altitude sickness and ultimately hypoxia.
Another effect of a depressurized cabin can be “the bends.” This is the same thing scuba divers can get if they resurface too quickly. A dramatic drop in pressure can cause excess nitrogen to come out of the blood stream as gas bubbles. This can result in joint pain, paralysis, and death. To prevent all of these complications, the cabins of many aircraft are pressurized to near sea level pressure, which makes breathing in an airplane about the same as breathing at sea level.