Question

Why does a patient with ADA deficiency require a repeated infusion of genetically engineered lymphocytes?

• A. They are unable to produce WBC.
• B. Immune response is hampered
• C. Blood coagulation donot take place.
• D. Both A and B

Answer 1

The correct option is D Both A and B

• ADA deficiency is also called adenosine deaminase deficiency. It is an autosomal recessive metabolic disorder. It results in immunodeficiency.
• The immune response of an individual is hampered. Its symptoms include pneumonia, chronic diarrhea, skin rashes.
• It can be treated by a bone marrow transplant in which healthy immune cells are used to replace the defective immune cells.
• Other treatment includes a repeated infusion of genetically engineered peripheral blood lymphocytes as they are unable to produce WBC.

Thus, the correct answer is option D.