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Question

Why does Bt toxin not kill the bacteria that produce it?


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Solution

Bt toxin

  1. Bacillus thuringiensis (Bt) is a bacterium usually found in the soil that normally delivers a poison that is deadly to specific herbivorous bugs.
  2. Bt-toxin does not kill the bacteria that produce it because it exists as protoxins, which is inactive.
  3. It gets activated by the alkaline pH of the gut and therefore acts on the stomach lining and causes the formation of holes.
  4. At the point when a bug ingests these proteins, they are initiated by proteolytic cleavage.
  5. The N-end is cut in the proteins as a whole and a C-terminal expansion is severed in certain select proteins.
  6. When enacted, the endotoxin binds to the stomach epithelium and causes cell lysis by the development of cation-specific channels, which prompts immediate death.

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