Nuclear reactions appear to violate both the Laws of Conservation of Mass and Energy because mass is converted into energy or vice versa.
However, the concept of mass-energy equivalence that emerges as a consequence of Einstein's General Theory of Relativity makes the Laws of Conservation of Mass and Energy special limiting cases of the Law of Conservation of Mass-Energy. Since mass is now a form of energy, we can convert back and forth as long as there is no net loss between the two.
The equivalence of mass and energy comes from Einstein's famous E=mc^2where c is the speed of light (in a vacuum).