It is the theory of relativity. It is the formula for Energy released on destruction of a mass.
Now, E=mc2
here, E stands for energy released on destruction of mass 'm' and c is the speed of light in vacuum.
Now, If 1 unit of mass is destroyed then, by theory of relativity,
E=(1)(3*108)2
=> E= 9*1016 J Therefore, 9*1016 J of energy is released.