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Question

Why is haemophilia rare in human females ? Mention a clinical symptom for the disease.

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Solution

Haemophilia is a inherited X-linked recessive inherited disorder that occurs rarely in the females.In this disorder one of the proteins involved in the cascade of blood coagulation is absent resulting from the deficient chromosome. The mothers are usually carriers for the disease. For a female to be haemophilic, the mother should be carrier and the father should be haemphilic which is again a very rare condition. The genotype for the hemophilic female can be represented by XHXH .
The clinical symptom of the disease is profuse bleeding resulting from a simple cut or injurey as the blood do not clot. This may lead to serious condition like death if not taken care of.


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