A biological form's nucleotide sequence, extrachromosomal DNA, or an infection's genome are all examples of extrachromosomal DNA that can undergo transformation.
Transformation can either have no impact or modify the outcome while also impeding the quality's ability to function as intended.
There are two types of change: (1) significant transformation, which occurs in body cells but is not passed on to the children, and (2) microbial line transformation, which occurs in the sex cell of an organic entity but may also affect the progeny.
A missense mutation is a mistake in the DNA that results in the integration of an undesirable amino acid into a protein as a result of changing a single nucleotide in the DNA. The finest example of a missense alteration is a pallor known as sickle cell anaemia.
In the beta-globin chain, there is an adjustment of codon from GAG to GTG which replaces glutamine with valine in the sixth position.