the very heavy nuclei will tend to move to a more stable configuration. They do this by becoming lighter. They do this by emitting an alpha particle (2 protons and 2 neutrons). They will do this repeatedly (interspersed with some beta minus decay to reduce the neutron to proton number) until it reaches lead.
U-235 is less stable than U-238 because it has an odd number of neutrons (nuclei are more stable when their nucleons can pair up). Thus it has a shorter half life.
Since enriched uranium has a higher concentration of U-235 than natural uranium, it is more radioactive.